Chequers Brexit plan puts the Tories in a perilous position as Theresa May’s party sinks in the polls

Share Julian Harris Theresa May’s ongoing survival as Prime Minister is fascinating for the fact that it rests so heavily on the lack of a politically-viable, workable alternative.Her party, and Westminster as a whole, are so factious that no group has both the ability and the incentive to remove her from power, no matter how much they wish she was gone. Being caught in the middle of numerous Brexit-backing and Brexit-bashing factions is a daily headache for the PM but also the source of her continuity. whatsapp A hat-trick of opinion polls conducted since 10 July show Labour out in front, reversing a long string of surveys dominated by Tory leads. One shows the Conservatives plummeting six points in the wake of the Chequers deal, with another reflecting a four-point drop.Dig into the data and the picture is arguably worse. Three quarters say the government is doing “badly” at negotiating the UK’s exit from the EU, according to YouGov. Nearly seven in 10 people who voted for May’s party last year agree with this damning verdict. And just 13 per cent of people think the Chequers deal would be good for Britain.While the PM’s attempt to steer Brexit through a largely Remain-backing parliament is entirely understandable, the weekend’s polls are a bleak reminder of the dangers of focusing policy on Westminster rather than the wider electorate. Brexit has put the Conservatives in a perilous position, and with Jeremy Corbyn waiting in the wings, it is a peril that threatens the UK as a whole. Sunday 15 July 2018 10:12 am Chequers Brexit plan puts the Tories in a perilous position as Theresa May’s party sinks in the polls whatsapp May’s plan to push Brexit through parliament also, somewhat perversely, rests on this stalemate. Each time she is presented with a challenge, she manoeuvres just enough for the majority of MPs to view the government’s position as the lesser of two immediate evils.This tactic will be tested again on Monday when the taxation (cross-border trade) bill returns to the Commons. May’s message at the weekend, as she called for support for her Brexit position formulated at Chequers, was to “keep our eyes on the prize”.She added: “If we don’t, we risk ending up with no Brexit at all.”Read more: Another Tory resigns from Theresa May’s government over BrexitThe timing of her statement suggests the PM was directing her comments at parliamentary colleagues. However, her words, written in a national newspaper, were addressed to “the country”. The article could easily be seen as a response to the way the Chequers deal has gone down among voters. Ad Unmute by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeMisterStoryWoman Files For Divorce After Seeing This Photo – Can You See Why?MisterStoryUndoZen HeraldEllen Got A Little Too Personal With Blake Shelton, So He Said ThisZen HeraldUndoinvesting.comThe Military Spent $1 Billion On this New Vehicle, And Here’s The First Lookinvesting.comUndomoneycougar.comDiana’s Butler Reveals Why Harry Really Married Meghanmoneycougar.comUndoTotal PastThis Woman’s Obituary Was So Harsh, Her Son Was Left ReelingTotal PastUndoSwift VerdictChrissy Metz, 39, Shows Off Massive Weight Loss In Fierce New PhotoSwift VerdictUndoNoteableyFaith Hill’s Daughter Is Probably The Prettiest Woman In The WorldNoteableyUndoNovelodgeMan Pulls Hidden String In Scottsdale And Discovers Secret Room Filled With…NovelodgeUndoBridesBlushMeghan Markle’s Current Net Worth Is Causing The Queen To CringeBridesBlushUndo read more

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China pledges to go carbon neutral by 2060

first_imgChina today sprung a major surprise after President Xi Jinping called for a “green revolution” and said his country would be carbon neutral by 2060. whatsapp Share “The announcement today is also a major fillip for the European Union, whose leaders recently urged President Xi to take exactly this step as part of a joint push on lowering emissions, showing that international moves to curb climate change remain alive despite the best efforts of Donald Trump and [Brazilian president] Jair Bolsonaro in the run-up to next year’s COP26 in Glasgow.” Before the Open newsletter: Start your day with the City View podcast and key market data The move was welcomed by the EU, which has been negotiating with China to lay out a target for carbon neutrality. whatsapp (AFP via Getty Images) Also Read: China pledges to go carbon neutral by 2060 Xi hit back, saying China had “no intention to enter a Cold War with any country”. “Those who attack America’s exceptional environmental record while ignoring China’s rampant pollution are not interested in the environment. They only want to punish America. And I will not stand for it,” Trump said, a few minutes before Xi took to the virtual lectern. (AFP via Getty Images) China pledges to go carbon neutral by 2060 It is the first time that the world’s largest polluter has pledged to end its contribution to climate change.center_img Edward Thicknesse Addressing the UN general assembly today, Xi said that China would hit peak carbon emissions in 2030 and then begin to phase out emitting technologies. Richard Black, director of the Energy and Climate Intelligence Unit (ECIU) said: “China isn’t just the world’s biggest emitter but the biggest energy financier and biggest market, so its decisions play a major role in shaping how the rest of the world progresses with its transition away from the fossil fuels that cause climate change. The move is widely seen as heaping pressure on US President Donald Trump, who has previously called the Paris climate accords a one-sided agreement and attacked China’s “rampant pollution”. (AFP via Getty Images) Also Read: China pledges to go carbon neutral by 2060 Trump and Xi also exchanged blows over the coronavirus pandemic, with Trump calling for China to be held “accountable” for the crisis. In 2017, Trump pulled the US out of the Paris agreement and has subsequently rolled back hundreds of environmental protections. He insisted that the US had reduced its climate emissions by more than any other country involved in the agreement.  Tuesday 22 September 2020 8:45 pm “China will scale up its intended Nationally Determined Contributions (to the Paris agreement) by adopting more vigorous policies and measures,” the premier said. by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikePast Factory”Waltons” Actress Says Magazine Ended Her CareerPast FactoryDaily FunnyFemale Athlete Fails You Can’t Look Away FromDaily FunnyNoteableyJulia Robert’s Daughter Turns 16 And Looks Just Like Her MomNoteableybonvoyaged.comThese Celebs Are Complete Jerks In Real Life.bonvoyaged.comDefinitionThe 20 Worst Draft Picks Ever – Ryan Leaf Doesn’t Even Crack The Top 5DefinitionYourDailyLamaHe Used To Be Handsome In 80s Now It’s Hard To Look At HimYourDailyLamaJustPerfact USAMan Decides to File for Divorce After Taking a Closer Look at This Photo!   JustPerfact USAOne-N-Done | 7-Minute Workout7 Minutes a Day To a Flat Stomach By Using This 1 Easy ExerciseOne-N-Done | 7-Minute WorkoutZen HeraldEllen Got A Little Too Personal With Blake Shelton, So He Said ThisZen Herald Show Comments ▼last_img read more

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Londoners set to benefit most from parking ticket “grace period”

first_img whatsapp More From Our Partners A ProPublica investigation has caused outrage in the U.S. this weekvaluewalk.comKiller drone ‘hunted down a human target’ without being told tonypost.comAstounding Fossil Discovery in California After Man Looks Closelygoodnewsnetwork.orgRussell Wilson, AOC among many voicing support for Naomi Osakacbsnews.comBrave 7-Year-old Boy Swims an Hour to Rescue His Dad and Little Sistergoodnewsnetwork.orgFlorida woman allegedly crashes children’s birthday party, rapes teennypost.comPolice Capture Elusive Tiger Poacher After 20 Years of Pursuing the Huntergoodnewsnetwork.orgSupermodel Anne Vyalitsyna claims income drop, pushes for child supportnypost.comNative American Tribe Gets Back Sacred Island Taken 160 Years Agogoodnewsnetwork.orgWhy people are finding dryer sheets in their mailboxesnypost.comInside Ashton Kutcher and Mila Kunis’ not-so-average farmhouse estatenypost.comUK teen died on school trip after teachers allegedly refused her pleasnypost.comFeds seized 18 devices from Rudy Giuliani and his employees in April raidnypost.comKamala Harris keeps list of reporters who don’t ‘understand’ her: reportnypost.comMatt Gaetz swindled by ‘malicious actors’ in $155K boat sale boondogglenypost.comBiden received funds from top Russia lobbyist before Nord Stream 2 giveawaynypost.com‘Neighbor from hell’ faces new charges after scaring off home buyersnypost.comI blew off Adam Sandler 22 years ago — and it’s my biggest regretnypost.com Friday 6 March 2015 4:15 am Tags: NULL Londoners set to benefit most from parking ticket “grace period” by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeMoneyPailShe Was A Star, Now She Works In ScottsdaleMoneyPailMaternity WeekA Letter From The Devil Written By A Possessed Nun In 1676 Has Been TranslatedMaternity WeekGundry MD Bio Complete 3 SupplementTop Heart Surgeon: This Simple Trick Helps Empty Your Bowels Every MorningGundry MD Bio Complete 3 Supplementzenherald.com20 Rules Genghis Khan’s Army Had To Live Byzenherald.comFinancial 10See The Wife Of The World’s Richest BillionairesFinancial 10Magellan TimesThis Is Why The Roy Rogers Museum Has Been Closed For GoodMagellan TimesWorldemandCanal Drained For First Time And They Find ThisWorldemandComedyAbandoned Submarines Floating Around the WorldComedyNoteableyKirstie Alley Is So Skinny Now And Looks Like A BarbieNoteableycenter_img Jessica Morris whatsapp Show Comments ▼ Share Driving in London is often described as something akin to a nightmare – from traffic jams, to sky-high parking prices and pushy motorists. But there’s finally a bit of good news for the capital’s understandably frazzled drivers.Drivers will get a ten-minute window after a council parking ticket runs out before they can be fined as a result of a new law coming in next week. Communities Secretary Eric Pickles said he wanted to end the “war on drivers”. Individuals living or commuting into the capital are likely to be the biggest benefactors of the nationwide change. This is because, as research by the RAC Foundation shows, London boroughs make the most from parking income and penalties.Forty per cent of parking income is made in the city despite the fact Londoners own ten per cent of the UK’s cars. However, it’s also likely that commuters, who commute into London for work or a day out, also contribute.Of the top 30 income makers, 21 are London boroughs (of 33 London boroughs in total).  2011/122010/112009/10Change (%)1Westminster80.084.383.4-4%2Kensington & Chelsea42.836.537.614%3Camden39.339.241.0-4%4Hammersmith & Fulham31.128.324.925%5Wandsworth27.025.224.212%6Islington26.124.229.0-10%7Lambeth25.124.344.0-43%8Brighton & Hove UA23.623.121.69%9Ealing20.014.514.042%10Birmingham18.717.719.2-2%11Tower Hamlets17.516.816.56%12Newham17.213.112.142%13Brent16.913.714.814%14Hackney15.316.513.216%15Haringey14.813.012.024%16Cornwall UA14.013.913.91%17Barnet14.09.210.335%18Newcastle upon Tyne13.912.513.53%19Manchester13.712.511.124%20Leeds13.011.712.08%21Hounslow12.211.210.615%22Croydon11.914.616.0-25%23City of London11.110.09.320%24Southwark10.911.911.2-3%25Bristol UA10.89.99.711%26Enfield10.810.913.0-17%27Bath & North East Somerset UA10.712.311.4-6%28Guildford10.710.19.413%29Waltham Forest10.49.39.94%30Bromley10.310.09.59%  last_img read more

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LongRead / New Loadstar LongRead: The Panama Canal

first_img Since it opened its enlarged locks, the Panama Canal has won back all its market share of Asia-US east coast container traffic.According to The Loadstar’s latest LongRead, the ability of lines to move far larger ships through the waterway’s locks, coupled with cut-price tariff incentives by Panama on the return leg of the journey, designed to encourage lines to convert round-the-world services into Asia-US East coast pendulum services, the canal has been successful at reversing the shift of vessel loops to Suez during the last five years.“The performance of the locks has fulfilled and exceeded what we expected for the first two years,” said Silvia de Marucci, executive manager of the Panama Canal Authority’s economic analysis and market research division.“We closed the fiscal year with the news that our market share [on the Asia-US trade] has gone from 40-42% in 2015/2016 to 47% this year.”The canal’s share of this all-important tradelane – which represented 34% of its total traffic in fiscal year 2018 (October-October) – has fluctuated between a high of 57% in 2009 and a low of 11% when the canal was handed over by the US to Panama in 1999.The intermodal landbridge that links the west coast ports of the US and Canada to the east coast hinterland has seen its market share decline from a high of 86% in 1999 to around 31% currently, while Suez has seen its share slip back since the opening of the new locks in Panama.Prior to the expansion, the largest ships that could transit the canal were first-generation panamax vessels with a maximum 32.3-metre beam and 12-metre draught, equating to no larger than 5,100 teu capacity – small by current industry standards and no longer considered viable to operate in many major deepsea lanes.Operators are now able to deploy neopanamax vessels up to 365 metres length, 48.8 metres beam and with a draught of 15.2 metres and, depending on the detailed specifications, ships of around 13,000 teu nominal capacity – representing a paradigm shift for the industry.Francisco Crespo, Maersk marine manager for the US east coast, said Panama offered much more than just an old-fashioned shortcut for shippers and lines.“There are the obvious attractions of being able to move larger ships via the canal, but are there other secondary advantages of its widening. The positive impact of cargo consolidation in Panama and other areas in the region that have made this route more attractive than alternative routes like Suez.“The fact is that, having the ability to deploy larger ships through the Panama Canal has allowed Maersk Line to move bigger vessels from certain origins in Asia to the US east coast/Gulf.“For us, with the new locks, Panama is preferable for sailings from Shanghai and further north like Korea to ports south of New York.”With 32 feeder services linking Panamanian ports to other hinterlands, like the east and west coasts of South America and the Gulf of Mexico, the canal has benefited from its proximity to key markets.However, the arrival of bigger ships hasn’t been the fillip to Panamanian ports it was expected to be. Combined volumes in Panama’s container terminals registered no growth this year, following a 10% increase in 2017.The flat throughput figures follow the disappointment of receiving no bids for a concession to construct a new box hub, Corozal Container Terminal, on land adjacent to Hutchison Port Holdings Balboa, when it was tendered by the Panama Canal last year.Maersk’s APM Terminals, MSC’s Terminal Investment, CMA CGM’s Terminal Link and Singapore-based PSA International were all expected to submit the required specifications for the 5m teu capacity terminal. By Rainbow Nelson & Neil Dekker 12/11/2018 Read more…last_img read more

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News / Direct China-Europe rail service looking attractive to air shippers in a queue

first_img© Yzqblyxy By Alex Lennane 20/04/2020 “It is the language that air freight importers are more used to dealing with,” explained Tony Cole, head of supply chain services for Davies Turner. “It makes a comparison between the relative costs of the intermodal rail service and air freight more immediately obvious.“At the current rate of just $0.24 per kg or 2,000 cubic metre, with a minimum cost of $120, it is no surprise that our direct Express China Rail service is becoming of great interest to the air freight sector. They are facing sky-high air freight rates out of China; $10 to $15 per kg now being seen.“Importers that traditionally move freight by air only need to factor-in the slightly longer lead times for rail, to see what a massive cost saving they can benefit from. Importers that are able to remodel their supply chains to use the rail freight option may do so on a permanent basis.”Davies Turner offers a weekly express rail service from Xi’an to the UK via Duisberg, which was previously priced using the standard overland freight pricing of US dollars per cubic metre. Transit time is normally between 22 and 24 days, although some trains have been as quick as 17 days.However, it is thought that Chinese authorities are now checking increasing numbers of export boxes, which is expected to add some time to the journey.  One source said that many consignments of PPE have been misdeclared, holding up all exports.As one air freight forwarder noted, pointing to the failure of a UK government order for PPE equipment to arrive this weekend, due to be flown in by the Royal Air Force (RAF), “even the RAF, with British government backing, can’t get PPE here as scheduled.“It’ll be the Royal Navy moving containers next, to try and get us out of this deep, deep hole.”Boxes wait in Shanghai – videocenter_img Chaos in the air freight industry could lead to a greater reliance on rail on the Asia-Europe lane.As images of congestion in Shanghai began to arrive and forwarders report the challenges of sending goods by air, Davies Turner said shippers should look instead to rail.Air freight is experiencing little or no immediate booking capacity available, and there are waits of more than a week to get cargo on a flight out of Shanghai –and with prices at all-time highs, rail is looking increasingly attractive.To help shippers, Davies Turner said it would quote price per kilo.last_img read more

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At 88, this doctor won’t give up on a long-ignored treatment for strokes and heart attacks

first_img NewslettersSign up for The Readout Your daily guide to what’s happening in biotech. Newsletters Sign up for Daily Recap A roundup of STAT’s top stories of the day. Privacy Policy In the LabAt 88, this doctor won’t give up on a long-ignored treatment for strokes and heart attacks Related: STAT+: Exclusive analysis of biopharma, health policy, and the life sciences. Privacy Policy @kweintraub About the Author Reprints He’s a professor at Harvard Medical School, but in many ways, Dr. Victor Gurewich is an outsider.His research is funded by a small family foundation, and he hasn’t tried for a federal grant in decades. He’s a primary care doctor whose work tramples on the terrain of cardiologists and neurologists.So it’s perhaps not surprising that, more than 20 years after figuring out a combination therapy that he believes is a safer, more effective way to treat heart attacks and strokes, he’s had little success getting anyone to listen.advertisement “It’s a nifty idea. Who knows, maybe it’s a great idea.” The story begins in 1980, when Gurewich discovered a precursor to an enzyme, called urokinase plasminogen activator.We can survive cuts and bruises without bleeding to death because of our blood’s ability to form clots. The body also has a compensatory clot-busting system to dissolve clots that form inside blood vessels: tPA is part of that natural system; urokinase is, too.Urokinase was already being used as a clot-buster in people with clots in their lungs, but it sometimes led to brain bleeds, because it didn’t target just the clot.Gurewich’s urokinase precursor was less likely to lead to brain bleeds, because it was clot-specific, but when he published that finding, it had no impact. William Campbell loves worms. And they won him a Nobel Prize Although he hadn’t yet met Gurewich, del Zoppo was a big fan of urokinase in those days, and of the idea that drugs could be used within a few hours of a stroke to help the brain recover. He helped lead clinical trials of tPA, which proved more popular than urokinase, in part because it could be delivered more easily. Urokinase was injected into an artery in the thigh, while the doctor watched for the clot to dissolve. With tPA, doctors simply had to add a standard dose to a patient’s IV drip “and hope for the best,” said Mayer, of Henry Ford.Although tPA failed at least half the time, and could have devastating side effects, tPA became the standard of care, with the entire emergency care system redesigned to make sure stroke patients could receive it quickly enough, del Zoppo said.Gurewich was still convinced he had a better approach, so he went back to his lab, hoping to generate results that couldn’t be ignored.Gurewich points to data that show the efficacy of his combination drug treatment, as compared with tPA, in heart attack patients. Kayana Szymczak for STATGurewich has always loved the satisfaction of research.“As a boy, I was always taking things apart,” he said, laughing at his limited success at putting mechanical toys and other things back together. “It is fun to think about how something works.”He was 6 when his family fled Hitler’s Berlin. Gurewich was raised mostly in London and New York, where several German Nobel laureates were regular guests of his doctor father’s.He came to Boston in the late 1950s for medical school at Harvard, where a mentor encouraged him to pursue his curiosity and take up research projects on the side. It was an unusual activity for a practicing doctor at the time. Ever since, he’s balanced a half-time medical practice — he still sees patients four half-days a week, at Mount Auburn Hospital in Cambridge — and research.“I’m interested in blood vessels,” he said. People think of heart disease as occurring in the heart, but, really, most of the action happens in the coronary blood vessels, he said. Several heart and stroke specialists told STAT they knew nothing about Gurewich’s work, or else they dismissed his experimental therapy as outmoded.Others said he should keep plugging away to see whether his drug combination can be shown safe and effective in patients. “It’s a nifty idea. Who knows, maybe it’s a great idea,” said Stephan A. Mayer, chairman of neurology for the Henry Ford Health System in Detroit.Twenty-three years ago, Gurewich published a clinical trial in heart attack patients, showing his idea of combining two medications to break up blood clots had merit. But the company that ran the study was sold, and the buyer shut down its cardiology division. Since then, as he’s labored to get financial backing, another drug became the standard of care in stroke, while clot-busting drugs were abandoned as a treatment for heart attacks.“It’s just a remarkable story,” said Annalisa Jenkins, a British doctor and biotech executive who serves on the TSI board. She signed on, she said, because she believes in the science and wants to help the company succeed. She also believes in Gurewich.“I just love him to bits,” she said. “His whole life has been unraveling this [medical] pathway. … He’s not in it for the commercial success. It’s part of his legacy.”Built-in bookshelves in Gurewick’s office are lined with his lab notebooks, meticulously labeled and dating back to 1963. Kayana Szymczak for STATEnd up in a hospital today with a heart attack, and you’re likely to be rushed in for an emergency angioplasty. An interventional cardiologist will thread a catheter through your arteries until reaching the site of the blockage in your heart that caused the attack. By inflating a tiny balloon, the doctor will push the clot out of the way, allowing blood to flow through again.The faster the better, but many patients get to the hospital after the first few hours, when most of the damage happens.If, instead, you have a type of stroke caused by a similar blockage in the blood vessels of the brain, speed is also essential. A doctor may perform surgery to break up clots in larger vessels, but that procedure is still too risky in smaller ones. In those cases, you might receive a drug called tissue plasminogen activator, or tPA. If given within 4 1/2 hours after a stroke begins, the medication can help dissolve the clot, restore blood flow, and reduce brain damage. But tPA can also cause seizures and fatal brain bleeds, which makes some doctors reluctant to use it.Gurewich believes his treatment approach could solve both problems: The medications could quickly open up blocked vessels, providing stroke patients effective treatment at lower risk, and giving heart attack patients more time to get an angioplasty or — in areas or countries where the procedure is too expensive or readily available — an effective alternative.He has the type of scientific data that usually convinces medical minds to run a large clinical trial in the hopes of winning FDA approval of their drug. But Gurewich often feels like he’s tilting at windmills.“It’s all pretty obvious,” Gurewich said of his approach, because that’s how clots are naturally dissolved in the body. “What’s not so obvious is why it’s ignored.” Stephan A. Mayer, chairman of neurology for the Henry Ford Health System Related: Please enter a valid email address. By Karen Weintraub April 6, 2018 Reprints Brain organoids as repair kits for stroke damage inch closer to reality Gurewich is modest about his role in this discovery. “We didn’t invent anything,” he said. “We just figured out how it works, which is sometimes all it takes.”But it would take more than that.A European pharmaceutical company had licensed Gurewich’s form of pro-UK and funded the 1995 trial, after seeing his earlier, promising results. But the company was sold to another, which had different priorities and gave Gurewich back the license.He tried to find another company to support his research, but by the late 1990s and early 2000s, the field was focused on getting tPA into patients fast enough.Other people were tinkering with different drugs in this class, called thrombolytics. Some of these drugs fared well in mid-sized trials, but none made it all the way to market.Gurewich refused to give up. He set out to improve pro-UK’s main weakness: In the body, it quickly converted to urokinase and caused bleeding.He started TSI in 2006 to fund the work, and eventually, he came up with a modified version of pro-UK that converted to urokinase more slowly, and therefore was safer.By that point, though, the mixed results from tPA had so discredited the whole idea of such thrombolytic drugs in treating heart attacks that cardiologists dismiss the entire drug category out of hand. “We’ve moved away from thrombolytics for a long time now,” Robert Yeh, an interventional cardiologist at Beth Israel Deaconess Medical Center and Harvard Medical School, said via email. Heart attacks are instead treated with angioplasty. Leave this field empty if you’re human: In the early 1980s, when his research was federally funded, Gurewich figured out that urokinase and tPA functioned as a team in the body. But he didn’t understand how the process worked.One night, he woke up thinking about the problem. “It killed the rest of the night,” he said. But by first light, he had an idea: What if tPA worked like the starter motor that turns on a car, and urokinase was the gasoline that ran it?Back in his lab, he proved at least experimentally that he was right. When a clot forms, tPA in the bloodstream is quickly recruited to the site to begin dissolving it. But too much of a clot-buster could lead to bleeds, so once the process is sparked, the body rapidly clears out tPA. Urokinase comes along, carried on the surface of platelets and certain white blood cells, to finish the job.The mistake that everyone, including him, had made, Gurewich realized, was that they had treated patients with just one drug or the other. They needed both.One early study had found that tPA reopens blockages in about 45 percent of heart attack patients, but also leads to death in about 6 percent of them. In a 1995 clinical trial, Gurewich showed that the combination of tPA plus his urokinase precursor, called pro-UK, could open 82 percent of blockages. One out of his 101 patients died in the hospital — a death rate of just 1 percent. The trial was not a gold-standard randomized trial, however; it didn’t compare tPA head to head with the combination therapy. Please enter a valid email address. Now at age 88, Gurewich is still trying to convince his medical peers that he’s right, and a tiny company he started in 2006 is about to launch a clinical trial in Europe that he hopes will prove it.“I’m stubborn. I don’t give up,” he said during an interview in the modest Cambridge, Mass., offices of Thrombolytic Science International, where the built-in bookshelves are lined with his lab notebooks, meticulously hand-labeled and dating back to 1963. His long struggle to be heard offers insight into how promising research ideas sometimes fail to take hold — even in the face of favorable evidence — said Gregory del Zoppo, a University of Washington expert on stroke treatment who saw enough promise in Gurewich’s data to join the company’s clinical advisory board.   advertisement Dr. Victor Gurewich at his office in Cambridge, Mass. Kayana Szymczak for STAT Karen Weintraub Karen Weintraub is an independenthealth/sciencejournalist, journalism teacher, and bookauthor. Leave this field empty if you’re human: tPA is still considered valuable for stroke patients, though as many as 30 percent of patients who might benefit don’t receive it — at least in part, according to a recent New York Times story, because their doctors are dubious of its benefits.Gurewich feels strongly that giving tPA by itself is a bad idea. “It’s quite remarkable that they’re still using tPA alone,” he said. “It’s a bit of a scandal. More than a bit.”Now, Gurewich and TSI’s staff of one are poised to start a clinical trial in 100 stroke patients in the Netherlands in June, with the $1 million to $2 million cost picked up by the same private foundation that has kept the company going all these years. If Jenkins can help the company raise $5 million to 10 million in the next few months, it will launch a second trial in heart attack patients in London.Gurewich’s hope is that the clinical trials will finally prove to the world that his one-two punch can safely knock out clots in the heart and the brain. A successful pilot trial should be enough to convince a major pharmaceutical company to invest in the idea, buy up TSI, and conduct the larger, more expensive trials that would be needed to bring it to market, Jenkins said.Although stroke specialists are moving away from tPA now, in favor of surgery, Dr. David Liebeskind, a professor of neurology at the University of California, Los Angeles, said the right drug could still catch the field’s attention. To displace tPA, a new drug would have to be at least as safe, effective, and easy to use, he said. Cheaper would help, too. The price of tPA has recently rocketed up from about $2,000 to $8,700 per vial, he said.Gurewich remains perennially optimistic.“Now there’s a hope we really will get this on the market and used,” he said. Tags cardiologyneurologyresearchlast_img read more

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Invesco broadens mandate of Trimark Advantage Bond Fund

first_img NEO, Invesco launch four index PTFs Facebook LinkedIn Twitter Related news Toronto-based Invesco Canada Ltd. said Thursday it has filed an amendment to its simplified prospectus to permit the portfolio management team of Trimark Advantage Bond Fund to invest a portion of its assets in other fixed income mutual funds managed by Invesco Canada or its affiliates. The portfolio management team plans to invest in funds within the Trimark fixed income lineup. The investment strategies of the underlying funds will be to invest mainly in high-yield debt securities. IE Staff Keywords Fund managersCompanies Invesco Canada Ltd. center_img Change to Counsel Global Small Cap Fund Invesco says the portfolio management team will consider a variety of factors when determining an investment in the underlying funds, including performance and risk attributes, as well as any trading and operational efficiencies that the fund may gain from investing in the underlying funds, rather than investing directly in securities. Franklin Templeton renames funds with new managers Share this article and your comments with peers on social medialast_img read more

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Canada’s economic growth slows in third quarter

first_img Share this article and your comments with peers on social media Statistics Canada says the pace of economic growth in Canada slowed in the third quarter.The federal agency says real gross domestic product grew at an annualized rate of 1.3% in the three-month period. Federal deficit reached $268B in January Facebook LinkedIn Twitter CMHC reports annual pace of housing starts down in December Canadian Press Raise and fall of business indicators green and red arrows maxicam/123RF Related news Keywords Economic indicatorsCompanies Statistics Canada Federal deficit reaches $248.2B three-quarters into fiscal 2020-21 It also revised its reading for the second quarter to show growth at an annual rate of 3.5% compared with its initial estimate of 3.7% released in August.Economists had expected annualized growth of 1.2% in the third quarter, according to financial markets data firm Refinitiv.The latest reading on the economy comes ahead of the Bank of Canada’s interest rate announcement next week.The central bank is widely expected to keep its key interest rate target on hold.last_img read more

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Prime Minister’s opening statement to House of Commons on UK-EU deal 30 December 2020

first_imgPrime Minister’s opening statement to House of Commons on UK-EU deal 30 December 2020 Thank you Mr Speaker, can I begin by thanking you and the House authorities and all your staff and their hard work in allowing us to meet today, and can I also welcome the outstanding news that AstraZeneca is now rolling out a new UK made vaccine approved by the MHRA that offers the hope to millions in this country and around the world, Mr Speaker I beg to move that the Bill be now read a second time,and having taken back control of our money, our borders, our laws and our waters by leaving the European Union on Jan 31st, we now seize the momentto forge a fantastic new relationship with our European neighbours, based on free trade and friendly co-operation.And at the heart of this Bill is one of the biggest free trade agreements in the world, a comprehensive Canada-style deal, worth over £660 billion,which, if anything, should allow our companies to do even more business with our European friends,safeguarding millions of jobs and livelihoods in our UK and across the continent.In less than 48 hours, we will leave the EU single market and the customs union, as we promisedand yet British exporters will not face a sudden thicket of trade barriers,but rather, for the first time in the history of EU agreements, zero tariffs and zero quotas.And just as we have avoided trade barriers, so we have also ensured the UK’s full control of our laws and our regulationsand there is a vital symmetry between those two achievements,because the central purpose of this Bill is to accomplish something that the British people always knew in their hearts could be done,but which we were continually told was impossible, we were told we could not have our cake and eat it, do you remember how often we were told that Mr Speaker,namely that we could trade and cooperate with our European neighbours on the closest terms of friendship and goodwill,whilst retaining sovereign control of our laws and our national destiny.And that unifying thread runs through every clause ofthis Bill, it embodies our vision – shared with our European neighbours –of a new relationship between Britain and the EU as sovereign equals,joined by friendship, commerce, history, interests and values, while respecting one another’s freedom of action and recognising that we have nothing to fear if we sometimes choose to do things differentlyand we have much to gain from the healthy stimulus of competition. And this Bill demonstrates therefore how Britain can be at once European and sovereign.And I think you’ll agree Mr Speaker our negotiators accomplished their feat with astonishing speed.It took nearly 8 years for the Uruguay Round of world trade talks to produce a deal,and five years for the EU to reach a trade agreement with Canada, six for Japan.We have done this in less than a year, in the teeth of a pandemic,and we have pressed ahead with this task, resisting all the calls for delay, Mr Speakerprecisely because creating certainty about our futureprovides the best chance of beating Covid and bouncing back even more strongly next year. And that was our objective.So I hope the House will join me in commending my Noble Friend Lord Frost and every member of his team for their skill, their mastery and their perseverance in translating our vision into a practical agreement.And let me also pay tribute to President Ursula von der Leyen, Michel Barnier and all our European friends for their pragmatism and foresightand for their understanding that it is profoundly in the interests of the EU to live alongside a prosperous, contented and sovereign United Kingdom.The House understands the significance of the fact that the basis of this agreement is not EU law but international law,so there is no direct effect,the EU law will no longer have any special status in the UKand there is no jurisdiction for the European Court of Justice.We will be able to design our own standards and regulations,And Mr Speaker the laws that this House of Commons passes will be interpreted – and I know this is of keen interest to honourable and right honourable members – solely by British judges sitting in British courts.We will have opportunity to devise new ways to spur and encourage the flourishing sectors in which this country leads the world,from green energy and life sciences to synthetic biology.We will be free Mr Speaker of EU state aid rules,We’ll be able to decide where and how we level up across our country with new jobs and new hope,including with freeports and new green industrial zones of a kind I’m sure he’d approve of.And if, in using our new freedoms, either Britain or the EU believes it is somehow being unfairly undercut,then subject to independent third party arbitration – and provided the measures are proportionate –either of us can decide, as sovereign equals, to protect our consumers.But this treaty explicitly envisages that any such action should be infrequentand it banishes the old concepts of uniformity and harmonisation in favour of the right to make our own regulatory choices and deal with the consequences.And Mr Speaker, every modern free trade agreement includes reciprocal commitments designed to prevent distortions of tradeand the true significance of the agreement embodied in this Billis that there is no role for the European Court of Justice,no ratchet clause on labour or environmental standardsand no dynamic alignment with the EU State Aid regime – or indeed any other aspect of EU law.In every respect, we have recovered our freedom of action.We will be free of the strictures of the Common Agricultural Policy,We’ll be able to conserve our landscapes and support our farmers exactly as we choose.And on Friday – for the first time 50 years – on Fridaythe UK will once again be recognised as an independent coastal state, regaining control of our waters,righting the wrong that was done by the Common Fisheries Policy throughout our EU Membership.And of course, I’ve always recognised Mr Speaker that this was going to be a difficult period for our European friends and partners, because they’ve been fishing in these waters for decades if not centuries and at first – as the House will know – they sought an adjustment period of 14 years,but our negotiators whittled that down to five and a half years,during which the UK’s share – in that five and a half years – the UK’s share of our fish in our waters will rise from over half today to around two thirds.And of course we would like to have done this more quickly,but it’s also true that once the adjustment period comes to an end, there will be no limit Mr speaker – other than the limits placed by the needs of science and conservation – on our ability to make use of our marine wealth,and 15 per cent of the EU’s historic catch from our waters will be returned to this country next year alone.And as I say to prepare our fishing communities for that moment, we will invest £100 million in a programme to modernise their fleets and the fish processing industry,Restoring Mr Speaker a great British industry to the eminence that it deserves, levelling up communities across the UK – particularly and including in ScotlandWhere their interests in my view have been neglected for too long.So I do find it extraordinary that on the eve of this great opportunity the declared position of the Scottish National nationalist Party is to hand control – with a small n – is to hand control of the very waters we have just reclaimed straight back to the EU. That is their policy Mr Speaker.And they plan to ensnare Scotland’s fishing fleet in the dragnets of the Common Fisheries Policy all over again.And, in the meantime, Mr Speaker – guess what they are going to do today – they are going to vote today for a “No Deal Brexit”,proving once and for all,that the interests of Scotland, England, Wales and Northern Irelandare best served by a One Nation party serving One United Kingdom.Mr Speaker, this deal was negotiated by a big team, and he should know this, from every part of our United Kingdom,and it serves the whole of the UK,not least by protecting the integrity of the United Kingdom single internal market and Northern Ireland’s place within it.Our points-based immigration system will end free movement and give us full control over who enters our country and by the way on that point I want to thank very much my right honourable friend the Chancellor of the Duchy of Lancaster for all he did to protect the interest of Northern Ireland.And at the same time the deal provides certainty for airlines and hauliers – who have suffered grievously during this pandemic –It guarantees the freedom of British citizens to travel to and from the EU, and retain access to healthcare.It provides certainty for our police, for our border forces, for our security agencies, who work alongside our European friends to keep our people safe. They are going to vote against this Mr Speaker.It provides certainty for our partnerships on scientific research,because we want our country to be a science superpower, but also a collaborative science superpower.And it provides certainty for business Mr Speaker.from financial services to our world leading manufactures, including our car industry,safeguarding highly skilled jobs and investment across our country.As for the Leader of the Opposition, Mr Speaker, I am delighted that he has found yet another position on Brexit,and having plunged down every blind alley and exhausted every possible alternative,he has come to the right conclusion,namely to vote for this agreement which this Government has secured.But alas the good news about the Labour party stops thereBecause I’m told the Right Honourable Gentleman intends to ask the British people for a mandate to rewrite the deal in 2024. That’s what he wants to do.I think frankly Mr Speaker we got Brexit done, let’s keep Brexit done,and let’s keep Brexit done, and let’s press ahead with this Government’s mission to unite and level up across our whole countryand grasp the opportunities before us.Because I have always said that Brexit is not an end but a beginning,and the responsibility now rests with all of us to make the best use of the powers that we have regained,and the tools that we have taken back into our hands.And we’re going to begin by fulfilling our manifesto promise to maintain the highest standards of labour and environmental regulation,because no caricature could be more inaccuratethan the idea of some bargain basement, Dickensian Britain,as if enlightened EU regulation has in the past been our only salvation from Dickensian squalor.Our national standards have always been among the very best in the worldand this House can be trusted to use its new freedom to keep them that way, without any outside invigilation.We are going to open Mr Speaker a new chapter in our national story, striking free trade deals around the world, adding to the agreements with 63 countries we have already achieved,and reasserting Global Britain as a liberal, outward-looking force for good.Detaching ourselves from the EU is only a prelude to the greater task of establishing our new role,and this country is contributing more than any other to vaccinate people across the world against Covidand leading the way in preventing future pandemics and we will continue to campaign for 12 years of quality education for every girl in the world and I thank my right honourable friend the Foreign Secretary for what he’s doing on that,and we will continue to lead the drive towards global net zero, as we host COP26 in Glasgow next year.And I hope and believe – and I think actually the tone this morning has given me encouragement in this belief Mr Speaker – the mood in the House this morning which seems to me on the whole to be positive. I hope in spite of the as usual, thin, synthetic, confected indignation that we hear from some of the benches opposite – I hope and believe that this agreement will also serve to end some of the rancour and recrimination that we’ve had in recent years,allow us to come to together as a country, to leave old arguments, old desiccated super masticated arguments behind, move on and build a new and great future for our country.Because those of us who campaigned for Britain to leave the EU never sought a rupture with our closest neighbours.We never wanted to sever ourselves from fellow democracies beneath whose soil lie British war graves in tranquil cemeteries,often tended by local schoolchildren,testament to our shared struggle for freedom and everything we cherish in common.What we wanted was not a rupture but a resolution, a resolution of the old, tired, vexed question of Britain’s political relations with Europe, which has bedevilled our post-War history. First, we stood aloof, then we became a half-hearted, sometimes obstructive member of the EU.Now, with this Bill, we are going to become a friendly neighbour – the best friend and ally the EU could have – working hand-in-glove whenever our values and interests coincide while fulfilling the sovereign wish of the British people to live under their own laws, made by their own elected Parliament.That is the historic resolution delivered by this Bill and Mr Speaker I commend it to the House. /Public Release. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. View in full here. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:Canada, EU, Europe, European Union, financial services, Government, healthcare, immigration, Ireland, Japan, Prime Minister, synthetic biology, UK, UK Government, United Kingdom, Uruguaylast_img read more

Read more on Prime Minister’s opening statement to House of Commons on UK-EU deal 30 December 2020

This model of the new Batmobile shows off its muscle car influences

first_img PlayThe Rolls-Royce Boat Tail may be the most expensive new car everPlay3 common new car problems (and how to prevent them) | Maintenance Advice | Driving.caPlayFinal 5 Minivan Contenders | Driving.caPlay2021 Volvo XC90 Recharge | Ministry of Interior Affairs | Driving.caPlayThe 2022 Ford F-150 Lightning is a new take on Canada’s fave truck | Driving.caPlayBuying a used Toyota Tundra? Check these 5 things first | Used Truck Advice | Driving.caPlayCanada’s most efficient trucks in 2021 | Driving.caPlay3 ways to make night driving safer and more comfortable | Advice | Driving.caPlayDriving into the Future: Sustainability and Innovation in tomorrow’s cars | Driving.ca virtual panelPlayThese spy shots get us an early glimpse of some future models | Driving.ca Buy It! Princess Diana’s humble little 1981 Ford Escort is up for auction An engagement gift from Prince Charles, the car is being sold by a Princess Di “superfan” Trending in Canada Trending Videos There’s more than a dose of classic Dodge Charger here, along with a helping of Camaro and Mustang. Perhaps young Mr. Wayne took advantage of current employee pricing deals coming out of Detroit.Naturally, these cars are always flights of fancy, so trying to imagine what would be powering this thing is a fool’s errand.Suffice it to say the mock-up has an engine of some description slung behind the driver, complete with angry-looking manifolds and what appears to be a set of exhaust pipes exiting just fore of the side doors. Knowing the franchise, there’s likely going to be all manner of weaponry on board as well.The model’s red illumination and general colours, intentionally or not, recall the Batmobiles driven by Adam West fifty-odd years ago. This is a Very Good Thing.That same lighting extends to the grille area between the headlights, giving it a KITT-like appearance. There’s nothing wrong with that callback, either. The overhead shot shows off bodywork that flares to the car’s rear, evoking the Batmobile driven by Michael Keaton in the 1989 reboot.There’s every chance in the world the car we see on screen will change between now and when the movie is released, currently scheduled for next October. Hollywood magic can make awesome things appear on screen but the demands of filming does sometimes require designers to rein a few outlandish features.Thankfully, whatever has to be removed from this design in order to make it work can likely be added back in with the help of CGI. RELATED TAGSDodgeCoupeFlexNew VehiclesbatmanbatmobileFlexMovie Cars COMMENTSSHARE YOUR THOUGHTS advertisementcenter_img If there’s one thing most gearheads look for in the upcoming installment of a long-running movie franchise, it’s the arrival of new wheels for the film’s protagonist or anti-hero.Batman has had plenty of cool rides over the years, but this concept that’s set to appear in next year’s reboot of the series is one of the best yet.Mixing a dose of Batman theatre with Mad Max-style aggression, the new Batmobile is a departure from the not-of-this-world Tumbler that’s shown up recently in the Bat Bunker underground lair. We encourage all readers to share their views on our articles using Facebook commenting Visit our FAQ page for more information. What do you think? Where does this concept rank in terms of your favourite Batmobile? See More Videos The Rolls-Royce Boat Tail may be the most expensive new car ever ‹ Previous Next ›last_img read more

Read more on This model of the new Batmobile shows off its muscle car influences